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SPA是研究精子受精过程,评价男性生育力的有效生物模型。SPA 与 RSA,PCT,MPT,HOS,ATP,Ah,Vp 的相关性一直存在争论。SPA 在男性不育症,尤其是特发性和不明原因的不育患者的诊断以及对人类 IVF 成功率的预测价值是肯定的。目前,趋向采用10％SPA穿透平作为判断男性生育力和选择 IVF-ET 病例的临界值。但仍存在10～20％的假阴性,提示在判断 SPA 结果,尤其是阴性结果时应特别谨慎并做必要的重复。同时,SPA 也是指导治疗,监测疗效的重要手段。
SPA is an effective biological model to study sperm fertilization process and evaluate male fertility. The correlation between SPA and RSA, PCT, MPT, HOS, ATP, Ah, Vp has been controversial. The diagnosis of infertility in male infertility, especially in patients with idiopathic and unexplained infertility, and the predictive value of the success rate of human IVF are affirmed. At present, 10% SPA penetration is the trend to judge the male fertility and select the threshold of IVF-ET cases. However, a false negative of 10-20% is still present, suggesting that caution should be exercised and the necessary duplication should be made when judging SPA results, especially negative ones. At the same time, SPA is also an important means to guide treatment and monitor curative effect.