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目的:研究新疆地区慢性化脓性中耳炎主要致病菌的种类及耐药情况。方法:对住院慢性化脓性中耳炎患者的分泌物进行细菌培养鉴定及药物敏感试验。结果:分离出89株细菌,金黄色葡萄球菌33株(37.1%),铜绿假单胞菌21株(23.6%)。金黄色葡萄球菌对莫西沙星、利奈唑烷、喹努普汀、利福平、替考拉宁、苯唑西林、亚安培南、氨苄西林/舒巴坦、万古霉素、磷霉素有较高的敏感性。所有金黄色葡萄球菌对莫西沙星及利奈唑烷未检出耐药株。铜绿假单胞菌对庆大霉素、头孢哌酮/舒巴坦、哌拉西林/他唑巴坦、丁胺卡那霉素、哌拉西林、头孢他啶、头孢吡肟、妥布霉素有较高的敏感性。结论:金黄色葡萄球菌和铜绿假单胞菌是新疆地区的慢性化脓性中耳炎主要致病菌,临床医生应根据药敏结果合理使用抗生素。
Objective: To study the types and drug resistance of major pathogens in chronic suppurative otitis media in Xinjiang. Methods: Bacterial culture identification and drug sensitivity test were performed on the secretions of hospitalized patients with chronic suppurative otitis media. Results: 89 strains of bacteria were isolated, 33 strains of Staphylococcus aureus (37.1%) and 21 strains of Pseudomonas aeruginosa (23.6%). Staphylococcus aureus is resistant to moxifloxacin, linezolid, quinuptin, rifampicin, teicoplanin, oxacillin, amphetamines, ampicillin / sulbactam, vancomycin, Higher sensitivity. All Staphylococcus aureus did not detect resistant strains to moxifloxacin and linezolid. Pseudomonas aeruginosa against gentamicin, cefoperazone / sulbactam, piperacillin / tazobactam, amikacin, piperacillin, ceftazidime, cefepime, tobramycin are Higher sensitivity. Conclusion: Staphylococcus aureus and Pseudomonas aeruginosa are the main pathogens of chronic suppurative otitis media in Xinjiang. Clinicians should make rational use of antibiotics based on their susceptibility results.