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目的:比较滋阴泻火与疏肝理气中药方剂治疗女童性早熟的疗效。方法:采用随机、双盲、对照分组的方法,患儿分为治疗组(滋阴泻火方早熟Ⅱ号)、对照组(疏肝理气方逍遥丸);双盲、双模拟给药。随访比较用药前后两组患儿乳核指数、乳房Tanner 分期、中医证候积分、B 超检查(子宫、卵巢容积、最大卵泡直径)、骨龄的变化。132例患儿完成所有随访。结果:两组患儿用药前后比较,治疗组乳核指数、乳房 Tanner 分期、中医证候积分减少程度优于对照组(P<0.05或 P<0.01);B 超检查子宫、卵巢容积,卵泡大小,治疗组控制程度均优于对照组(P<0.05或 P<0.01);骨龄改变比较,两组差异无显著性(P>0.05)。结论:滋阴泻火中药早熟Ⅱ号治疗女童性早熟疗效优于疏肝理气中药逍遥丸。
Objective: To compare the curative effect of Ziyin Xiehuo and Shugan qi Chinese herbal prescriptions on precocious puberty in girls. Methods: The children were divided into treatment group (Ziyu Xiehuo PrescriptionⅡ) and control group (Shugan Liqi Prescription) at a randomized, double-blind and control group. The changes of breast nuclear index, breast Tanner staging, TCM syndrome score, B-ultrasound (uterus, ovarian volume, maximal follicle diameter) and bone age were compared between the two groups. 132 children completed all follow-up. Results: Compared with the control group (P <0.05 or P <0.01), the reduction of breast milk core index, breast Tanner staging and TCM syndrome scores in the two groups were significantly lower than those in the control group before and after treatment. The levels of uterus, ovarian volume, (P <0.05 or P <0.01). There was no significant difference between the two groups (P> 0.05). Conclusion: Ziyin Xiehuo premature Ⅱ treatment of girls in precocious puberty is better than Shugan qi medicine Xiaoyao Pill.