论文部分内容阅读
作者介绍了一种可靠的、化疗引起粘膜炎的动物模型,其粘膜炎与在人类出现的极为相似. 材料和方法应用仔雄性金色叙利亚大田鼠,按60mg/kg 5-Fu分别在第0、5、10天对12只大田鼠进行三次腹膜内注射。为了模拟慢性刺激的临床效果,用18号针尖对大田鼠颊囊粘膜进行表面搔抓,以线状方式来回穿过外翻的颊囊,每天一次,直至出现红斑,大多数动物,只需进行1～2天搔抓即出现红斑,无1例超过3天。作为对照组的4只大田鼠,仅给予颊囊粘膜表面刺激3天.
The authors describe a reliable animal model of chemotherapy-induced mucositis with mucositis that is very similar to that found in humans. Materials and Methods Application Male Golden Syrian Mole, at 60 mg/kg 5-Fu, at 0, Five intratumoral injections of 12 vole rats were performed on days 5 and 10. In order to simulate the clinical effect of chronic stimulation, the surface of the cheek pouch mucosa of the field mouse was scratched with a 18-gauge needle and passed through the everted cheek pouch in a linear manner once a day until erythema appeared. Most animals only need to perform The erythema appeared on scratching for 1 to 2 days, and none of the cases exceeded 3 days. As a control group, only 4 mice were given cheek pouch mucosal surface stimulation for 3 days.