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应用两种国产左氧氟沙星片治疗急性细菌性感染170 例,其中随机对照组131 例(试验组65例,对照组66 例)、开放试验组39 例。两药剂量均为每次100m g、每日3 次、疗程7～10d;病情偏重者可增为每次200m g,疗程可酌情延至14d。结果表明,试验组与对照组的总痊愈率和总有效率分别为72.31% 与74.24%和92.31% 与95.45% ;细菌清除率分别为91.53% 与93.33% ,以上结果经统计学处理均无显著性差异(P>0.05)。开放组总痊愈率和总有效率分别为71.79% 和100.00% ;细菌清除率为97.30% 。随机对照两组和开放组的不良反应发生率分别为10.77% 、12.12% (P> 0.05)和7.69% ,以恶心最多见,其次为头晕、失眠,均呈轻度,勿需特殊处理。以上结果提示,两种国产左氧氟沙星片同样安全、有效
Two kinds of domestic levofloxacin tablets were used in the treatment of 170 cases of acute bacterial infections, of which 131 cases were randomized (65 cases in trial group and 66 cases in control group) and 39 cases in open trial group. The two doses are 100m g each time, 3 times a day, the course of treatment 7 ~ 10d; those who are more likely to be increased for each 200m g, treatment may be extended to 14d, where appropriate. The results showed that the total cure rate and total effective rate of the experimental group and the control group were 72.31% and 74.24% and 92.31% and 95.45% respectively, and the bacterial clearance rates were 91.53% and 93.33% respectively. The above results were not statistically significant Sex differences (P> 0.05). The total cure rate and total effective rate of open group were 71.79% and 100.00% respectively; the bacterial clearance rate was 97.30%. The incidences of adverse reactions in the two randomized and open groups were 10.77%, 12.12% (P> 0.05) and 7.69%, respectively, with the most common nausea, followed by dizziness and insomnia, all without mild treatment. The above results suggest that the two domestic levofloxacin tablets equally safe and effective