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清醒大白鼠ip羊蹄角碱水解提取物1g/kg,血压无明显变化;ip 2g/kg,血压降低30～45％,持续180分钟以上。麻醉犬iv羊蹄角碱水解提取物25mg/kg,血压呈双相反应,短暂升高后逐渐降低,180分钟时基本恢复正常;iv100mg/kg,可使血压明显降低,维持4小时左右逐渐恢复,此种降压作用可被去甲肾上腺素所对抗。羊蹄角和羚羊角碱水解液,水煎液对离体蟾蜍心脏均有抑制作用。羊蹄角碱水解液可使大鼠、犬的心率减慢,在心率恢复时心电R波电压升高,可能与心率减慢、血压降低,反射性引起交感神经兴奋有关。
Awake rats ip Hydraps alkali hydrolysis extract 1g/kg, no significant change in blood pressure; ip 2g/kg, blood pressure decreased by 30 to 45% for more than 180 minutes. Anaesthetized dog iv Hydrahide alkali hydrolysis extract 25mg/kg, blood pressure was biphasic response, gradually decreased after a brief increase, basically returned to normal at 180 minutes; iv100mg/kg, can significantly reduce blood pressure, maintain a gradual recovery of about 4 hours, This antihypertensive effect can be counteracted by norepinephrine. The hooves and horn corn hydrolyzate, decoction have inhibitory effect on the isolated heart. Hydration of alkaline solution of sheep’s hooves can slow the heart rate of rats and dogs, and the R-wave voltage of the heart will rise when the heart rate recovers, which may be related to the decrease of heart rate, blood pressure, and sympathetic nerve activity caused by reflex.