内源性类阿片肽(Endogenous opioids)是指由机体产生的具有与吗啡(鸦片有效成分)相似生理作用的一些肽类物质,包括脑啡肽、内啡肽、强啡肽、皮啡肽和新皮啡肽等,其作用相当广泛,以镇痛方面的研究较多,但目前对其镇痛的作用原理仍不甚了解.新皮啡肽(Deltorphins)是1989年从一种南美洲树蛙的皮肤中发现的具有很强镇痛活性的一类神经肽,它选择性地结合δ受体.从文献检索看出,有关新皮啡肽的整体镇痛活性及对免疫功能的影响等方面的研究还未见报道,新皮啡肽Ⅱ的构象的研究也未见报道. Endogenous opioids are peptides that are produced by the body and have physiological similarities to morphine (opium), including enkephalins, endorphins, dynorphins, dermorphins and Neprididin and so on, it has a wide range of effects and many studies on analgesia, but its principle of analgesia is still not well understood at present.Deltorphin was obtained from a South American tree A class of neuropeptides with strong analgesic activity found in the skin of frogs, which selectively binds to delta receptors.From the literature search, the overall analgesic activity of nepridin and its effect on immune function, etc. Studies have not been reported, the study of the conformation of nepridin Ⅱ has not been reported.