供肾热缺血时是指在常温下,肾脏缺血或血液灌注严重不足的时间。在这段时间内,由于缺血、缺氧,肾组织内可产生一系列变化,使移植后植肾功能受到损害。较长时间的热缺血损伤常可引起术后移植物早期无功能(INF),这不仅增加鉴别诊断早期肾功能低下原因的困难,增加环胞素A的肾毒性,且可增加排异反应的发生,减低生存率。近年来,国内外许多学者对热缺血损伤的机制及防治进行了研究,现综述如下。肾脏热缺血损伤的病理生理变化 Renal ischemia is referred to at room temperature, renal ischemia or severe hypoperfusion time. During this time, due to ischemia, hypoxia, renal tissue can produce a series of changes, impaired kidney function after transplantation. Long-term ischemic injury can often lead to early postoperative graft loss of function (INF), which not only increases the differential diagnosis of early renal dysfunction difficulties, increased nephrotoxicity of cyclosporin A, and can increase the rejection The occurrence, reduce the survival rate. In recent years, many scholars at home and abroad on the mechanism of hot ischemic injury and prevention and treatment were studied, are summarized below. Pathophysiological changes of renal ischemic injury