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在N,N′-亚甲基二丙烯酰胺(Bis)存在的条件下,以偶氮二异丁腈(AIBN)为引发剂,使苯乙烯单封端聚乙二醇(St-PEG)大分子单体与丙烯酸(AAc)在3-戊酮溶液中进行分散共聚反应,得到了聚乙二醇-co-聚丙烯酸(PEG-co-PAAc)交联微球.动态激光光散射测试结果表明,所得的交联微球具有良好的单分散性;同时发现,在共聚反应中St-PEG大分子单体、AAc和Bis溶液浓度对交联微球粒径有明显的影响;交联微球的Rh在pH为4.5附近突然增加,并在pH>7.0后保持不变,说明该PEG-co-PAAc交联微球具有明显的pH响应性.
In the presence of N, N’-methylenebisacrylamide (Bis), azobisisobutyronitrile (AIBN) was used as initiator to make the styrene monopoly-terminated polyethylene glycol Poly (ethylene glycol) -co-polyacrylic acid (PEG-co-PAAc) crosslinked microspheres were obtained by the dispersion copolymerization of acrylic acid (AAc) and 3-pentanone solution.The results of dynamic laser light scattering , And the obtained crosslinked microspheres have good monodispersity. At the same time, it was found that the concentrations of St-PEG macromonomer, AAc and Bis solution significantly affect the particle size of the crosslinked microspheres in the copolymerization reaction. The crosslinked microspheres Rh of the PEG-co-PAAc cross-linked microspheres increased sharply at a pH of 4.5 and remained unchanged at pH> 7.0, indicating that the PEG-co-PAAc cross-linked microspheres have obvious pH responsiveness.