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鼻变态反应疾病近年有明显增加趋势,为此,不断寻找新的、有效的抗鼻变态反应药物,是各国变态反应学者的努力方向。现将有关的日文文献综述如下。一、Ketotifen(商品名萨地酮,Zaditen)。首由瑞士发明,系一种抗组胺口服药物。化学结构为4-(1-甲基-4-吡啶)-4 H苯-环庚噻吩-10-H-延胡索酸盐。作用机理主要是抑制肥大细胞脱颗粒及组胺的游离。近来发现,它还具有抑制慢反应物质释放的作用。本品易经消化道吸收,吸收率高达80～100%,服药后1小时内显出作用,维持12小时。因此,一般推荐一日口服二次。据文献报导,对减轻喷嚏发作和减少鼻分
In recent years, there has been a marked increase in nasal allergy diseases. Therefore, the constant search for new and effective anti-nasal allergy drugs is the direction of the allergy scholars in various countries. The relevant Japanese literature is summarized below. First, Ketotifen (trade name sanudone, Zaditen). First invented in Switzerland, is an antihistamine oral drug. The chemical structure is 4- (1-methyl-4-pyridyl) -4Hbenzocycloheptane-10-H-fumarate. Mechanism of action is mainly to inhibit mast cell degranulation and histamine free. It has recently been found that it also has the effect of inhibiting the release of slow-reacting substances. This product is easy to digest absorption of the digestive tract, the absorption rate of up to 80 to 100%, within 1 hour after taking the drug showed a role for 12 hours. Therefore, it is generally recommended to oral twice a day. According to the literature, to reduce the incidence of sneezing and reduce nasal points