英国Ｈｕｂｂａｒｄ等报告，原因不明纤维化肺泡炎患者肺癌发病率高，但不受吸烟习惯的影响。研究者采用流行病学方法调查了８９０例原因不明纤维化性肺泡炎患者和５８８４名普通居民的肺癌发病率。结果显 示，和一般居民相比，原因不明纤维 化肺泡炎患者肺癌发病率显著增 加， Britain’s Hubbard et al reported that the incidence of lung cancer in patients with unexplained fibrotic alveolitis was high, but was not affected by smoking habits. The researchers used epidemiological methods to investigate the incidence of lung cancer in 890 patients with unknown fibrotic alveolitis and 5884 general residents. The results show that compared with the general population, the incidence of lung cancer in patients with unexplained fibrotic alveolitis increased significantly.