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氧哌嗪青霉素是一种新型广谱青霉素,对肠道细菌和绿脓杆菌较敏感,因而对治疗革兰氏阴性细菌性脑膜炎可能特别有效。本文作者探讨了化脓性脑膜炎(化脑)时氧哌嗪青霉素对血脑屏障的通透性问题。对10例成人化脑患者的脑脊液进行了分析,5例脑脊液培养到致病菌,其余5例由于在腰穿前已进行抗菌治疗,未分离到病原菌,以脑脊液的常规与生化变化确立化脑诊断。 10例化脑患者均接受3次氧哌嗪青霉素治疗,每8小时静脉注射4g,随后测定血液与脑脊液标本中的
Piperacillin Penicillin, a new broad spectrum penicillin, is more sensitive to gut bacteria and Pseudomonas aeruginosa and may be particularly effective in the treatment of Gram-negative bacterial meningitis. The authors investigated the permeability of penicillin to the blood-brain barrier in purulent meningitis (chemical brain). Cerebrospinal fluid was analyzed in 10 adult patients with brain disease. Five patients were challenged with cerebrospinal fluid (CSF), and the remaining five patients were treated with antimicrobial therapy before lumbar puncture. Pathogenic bacteria were not isolated and the brain was routinely and biochemically changed diagnosis. 10 patients with brain disease were treated with piperacillin 3 times, intravenous injection of 4g every 8 hours, followed by determination of blood and cerebrospinal fluid specimens