论文部分内容阅读
环丙沙星(ciprofloxacin,CPFX;环丙氟哌酸)是氟喹诺酮类抗菌药,对各种革兰阴性、革兰阳性菌均有较强的抗菌作用,治疗多种感染性疾病疗效良好且较为安全。由于该药与其他药物合用时有明显的相互作用,故可影响疗效或增加合用药物的毒性。本文就其与其他药物相互作用的药物代谢动力学(药动学)和药效学及其临床意义加以介绍。 1 药动学相互作用 1.1 吸收时的相互作用由于多价离子可与CPFX形成螯合物,故含镁(如氧化镁)和铝(如氧化铝、硫糖铝)抗酸剂可明显降低CPFX吸收,使血药浓度显著降低。如合用硫糖铝可使口服500 mgCPFX的血浆峰浓度(C_(max))由2.0μg/ml降低到0.2μg/ml,
Ciprofloxacin (CPFX; Ciprofloxacin) is a fluoroquinolone antibacterial drug against Gram-negative, Gram-positive bacteria have a strong antibacterial effect, the treatment of a variety of infectious diseases and effective More secure. As the drug when combined with other drugs have obvious interactions, it can affect the efficacy or increase the toxicity of the combination of drugs. This article describes its pharmacokinetics (pharmacokinetics) and pharmacodynamic interactions with other drugs and their clinical implications. 1 Pharmacokinetic Interactions 1.1 Absorption Interactions Since polyvalent ions form chelates with CPFX, antacids containing magnesium (such as magnesia) and aluminum (such as alumina, sucralfate) can significantly reduce CPFX Absorption, blood concentration significantly reduced. Such as the combination of sucralfate oral concentration of 500 mgCPFX peak plasma concentration (C max) decreased from 2.0μg / ml to 0.2μg / ml,