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目的探讨优甲乐干预131I治疗甲亢后致早发甲减的影响。方法 72例Graves病患者,按照随机分组原理分成2组,A组38例,单纯给予131I治疗作为对照组;B组34例,给予131I后从第20天起连续给予优甲乐片(100μg/天),共计20d。通过检测甲功、甲状腺彩超、甲状腺显像和摄碘率实验等检查来观察碘-131致早发甲低的临床干预效果。结果 131I治疗后,A组第3个月、6个月、9个月和12个月甲减发生率分别为:2.82%、3.38%、6.20%、7.89%;B组第3个月、6个月、9个月和12个月甲减发生率分别为:1.26%、2.85%,4.95%、5.88%(A组高于B组,P<0.05)。结论 131I治疗后早期给予患者优甲乐干预能有效降低甲减的发生。
Objective To investigate the effects of Euthyrox after 131I treatment of hyperthyroidism caused by early hypothyroidism. Methods Seventy-two patients with Graves’ disease were divided into two groups according to the randomization principle: group A (38 cases) and control group (131I). In group B, 131 cases were treated with 100 μg / Day), a total of 20d. Through the detection of thyroid function, thyroid ultrasound, thyroid imaging and iodine uptake test to observe the iodine -131 caused by early hypothyroidism clinical intervention. Results After 131I treatment, the incidences of hypothyroidism at the third month, the sixth month, the ninth month and the 12th month in group A were 2.82%, 3.38%, 6.20% and 7.89% respectively. In the third month, group B, 6 The incidences of hypothyroidism at months, 9 months and 12 months were 1.26%, 2.85%, 4.95% and 5.88% respectively (group A was higher than group B, P <0.05). Conclusion The treatment of Euthyrox early early after 131I treatment can effectively reduce the incidence of hypothyroidism.