粒细胞-巨噬细胞集落-刺激因子(GMCSF)为一种调节糖蛋白,能促使髓细胞祖代的增殖与分化成为粒细胞与巨噬细胞。体内的GM-CSF是由纤维细胞、内皮细胞、巨噬细胞与T-淋巴细胞等各种细胞产生。人体GM-CSF最初是从淋巴母细胞株的上清液中提得纯品,是一种以127个氨基酸的多肽为核心的糖蛋白,其遗传密码位于染色体5位的长臂上。 Granulocyte-macrophage colony-stimulating factor (GMCSF) is a regulator of glycoprotein that promotes the proliferation and differentiation of myeloid progenitor cells into granulocytes and macrophages. In vivo GM-CSF is produced by various cells such as fibroblasts, endothelial cells, macrophages and T-lymphocytes. Human GM-CSF, originally derived from the supernatant of lymphoblastoid cell lines, is a glycoprotein with a 127-amino-acid peptide as its core. Its genetic code is located on the long arm of chromosome 5.