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【目的】探讨原发性乳腺癌组织中 nm23基因表达及其临床意义。【方法】选取本院2012年1月至2013年12月收治的120例原发性乳腺癌患者为研究对象,采取 SP 法检测癌组织中 nm23基因表达情况,并分析其与临床病理特征的关系。【结果】120例原发性乳腺癌组织中,nm23基因阳性表达率66.7%(80/120)。临床分期中Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期 nm23基因表达阳性率分别为75.0%(15/20)、70.0%(35/50)、62.5%(26/40)、50.0%(5/10)；肿瘤≤2.0 cm、2.0~5.0 cm、>5.0 cm 的 nm23基因表达阳性率分别为75.0%(45/60)、67.5%(27/40)、40.0%(8/20)；浸润性癌与非浸润性癌 nm23基因表达阳性率分别为72.2%(65/90)、50.0%(15/30)；淋巴结转移中阴性、0~3个和>3个 nm23基因表达阳性率分别为75.0%(30/40)、70.0%(35/50)、50.0%(15/30)。nm23基因表达阳性率在临床 TNM 分期、肿瘤大小、病理分型、淋巴结转移中比较具有统计学有意义(P 5.0 cm respectively;the expression rate in invasive carcinoma and carcinoma in situ (non-invasive cancer)is 72.2% (65/90)and 50.0% (15/30);nm23 gene ex-pression positive rates in cases with negative lymph node metastasis,0-3 positive lymph nodes,and more than 3 positive lymph nodes are 75.0 % (30/40),70.0% (35/50),50.0% (15/30).There is a statistically significance of m23 gene ex-pression rate in different clinical TNM stages,tumor sizes,histological types,and lymph node status (P <0.05).[Con-clusion]The expression of nm23 gene in primary breast cancers is closely correlated to the clinical stages,tumor size,in-vasiveness,and lymph node metastatic status of the tumors.Positive expression of nm23 gene on primary breast cancers can be considered as an important negative prognostic factor.