Auran等(1972)首次研制成钩端螺旋体(简称钩体)外膜抗原,并证实外膜具有免疫原性,也能给实验性感染动物提供保护作用。以往认为外膜抗原仅产生群特异性凝集抗体,本文利用单克隆抗体(McAb)以阐明外膜抗原的种特异性决定簇。作者按Auran方法提取哥本哈根型钩体外膜,并制成一组24种McAb,由于24种McAb所产生血清学反应相同,本次使用一 For the first time, Auran et al. (1972) developed the outer membrane antigens of Leptospira (Leptospira) and confirmed that the outer membrane was immunogenic and could also provide protection for experimental infected animals. In the past that outer membrane antigen only produce group specific agglutination antibody, the use of monoclonal antibodies (McAb) to elucidate the outer membrane antigen-specific determinants. The authors according to Auran method to extract the outer membrane of the Copenhagen type hook, and made a group of 24 kinds of McAb, because of the 24 kinds of McAb serological reaction produced by the same, this time using a