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地方性氟中毒是广泛的一种地方性疾病。有学者研究发现长期摄入过量氟可导致典型的氟骨症、氟斑牙改变~([1-3])。笔者本研究旨在分析转化生长因子β1(TGF-β1)在氟中毒肾脏损害发生机制中的意义,提供一定指导意义,具体内容报告如下。1资料与方法1.1实验动物Wista大鼠36只,SPF级,♀♂各半,体质量(200±20)g,由北京维通利华公司提供,合格证号:SCXK(京)2007-0001。常规饲养1周,自由饮食、
Local fluorosis is a widespread endemic disease. Some scholars have found that prolonged intake of fluoride can cause the typical fluorosis, dental fluorosis change ~ ([1-3]). The author of this study aims to analyze the significance of transforming growth factor β1 (TGF-β1) in the pathogenesis of renal damage caused by fluoride poisoning, provide some guidance, the specific content is reported as follows. 1 Materials and Methods 1.1 Experimental animals 36 Wistar rats, SPF level, ♀ ♂ half, body weight (200 ± 20) g, provided by Beijing Vitalon Co., Ltd., certificate of conformity: SCXK (Beijing) 2007-0001 . General feeding 1 week, free diet,