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【目的】分析全身伽玛刀联合大剂量维生素C和K3治疗非小细胞肺癌（NSCLC ）的疗效及并发症。【方法】2008年1月1日至2011年4月20日本科室收住的194例NSCLC患者，其中142例采用全身伽玛刀联合大剂量维生素C和K3治疗（试验组），52例患者仅接受全身伽玛刀治疗（对照组）。试验组：根据病程、肿瘤部位、性质、体积确定放射总剂量、分割次数、时间，再行维生素C 、维生素K3每天静脉滴注，3次每周。第一周，维生素C 20 g及维生素K3200 mg。第二周维生素C 30 g及维生素K3300 mg。第3周及以后第4～8周，维生素C 50 g及维生素K3500 mg。对照组的伽玛刀治疗同试验组。观察两组患者临床疗效和副反应。【结果】试验组患者治疗2月后K PS评分较治疗前有所提高，而对照组无明显提高，试验组1、2年生存率分别为77．24％和59．28％，明显高于对照组（63．46％，40．4％），试验组总有效率（CR＋ PR＝71．0％）明显高于对照组（46．4％），且未见明显副反应。另外，实验组与对照组肿瘤＜3 cm组2年生存率明显高于肿瘤≥3cm组，两组肿瘤直径≤3cm组有效率均高于≥5 cm组。【结论】全身伽玛刀联合大剂量维生素C和K3治疗NSCLC的临床效果及安全性好，值得推广。NSCLC越早治疗疗效越好。“,”Objective]To analyze the efficacies and complications of whole body gamma knife and high‐dose vitamin C/K3 for non‐small cell lung cancer (NSCLC) patients .[Methods]From January 1 ,2008 to April 20 ,2011 ,a total of 192 NSCLC patients were assigned to receive whole body gamma knife alone ( n=52) and in combination with high‐dose vitamin C/K3 ( n=142) .According to the course ,tumor location ,nature and size ,total radiation dose ,split frequency and time were determined .Vitamin C/K3 was administered daily in‐travenously thrice weekly .During week 1 ,vitamin C was 20 g and vitamin K3 200 mg ;During weeks 3/4~8 , vitamin C 50 g and vitamin K3 500 mg .The side effects and efficacies of all patients were observed .[Results]The 1 and 2‐year survival rates of experiment group were much higher than those of control group (77 .24% vs 63 .46% ,59 .28% vs 40 .4% ) .The total effective rate of experiment group was obviously higher than that of control group (71 .0% vs 46 .4% ) .No significant side effects were detected in experiment group .In addition , the 2‐year survival rate of tumor < 3 cm group was significantly higher than that of tumor ≥3 cm group .And the effective rate of tumor ≤3 cm group was higher than that of group ≥5 cm .[Conclusion]The combined regimen of whole body gamma knife treatment plus high‐dose vitamin C/K3 is both safe and efficacious for NSCLC .It is worthy of wider popularization .Early treatment yields better efficacies .