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Since December 2019, several cases of coronavirus infected disease 2019 (COVID-19) have been reported in Wuhan City, Hubei Province. COVID-19 has been rapid spread in other provinces of China and abroad. The prevention and control of outbreak is particularly important. Based on the development of network and medical and health resources in the context of the Intet + era, this article discusses strategies for the prevention and control of COVID-19 in the Intet + era, and provides a reference for the implementation of COVID-19 prevention and control.