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目的:探讨尼尔雌醇联合米索前列醇对绝经后女性IUD取出前的临床疗效。方法:选择绝经后女性宫内节育器取出前患者128例,随机将患者分为观察组和对照组,每组64例。2组患者在进行宫内节育器取出术前均给予顿服尼尔雌醇。观察组则在此基础上于术前阴道放置米索前列醇。对2组患者宫颈软化程度及药物不良反应等指标进行对比分析。结果:与对照组相比,观察组充分软化的比率明显提高,而软化的比率明显降低,差别均具有统计学意义(P<0.05)。与此同时,与对照组相比,观察组发生恶心、呕吐的比率明显降低,差别均具有统计学意义(P<0.05)。讨论:采用尼尔雌醇与米索前列醇联合应用治疗绝经后女性宫内节育器取出术前的过程中,其疗效确切,毒副作用小,是绝经后女性宫内节育器取出术的理想治疗方法。
Objective: To investigate the clinical effect of nylestriol combined with misoprostol on pre-menopausal women with IUD removal. Methods: A total of 128 patients with premenopausal women before IUD removal were randomly divided into observation group and control group, with 64 cases in each group. Two groups of patients were given Dayton nilestriol before operation for IUD removal. On the basis of this, the observation group placed misoprostol in the vagina before surgery. Two groups of patients with cervical softening and adverse drug reactions and other indicators were analyzed. Results: Compared with the control group, the rate of softening in the observation group was significantly increased, while the rate of softening was significantly lower, with statistical significance (P <0.05). In the meantime, the rate of nausea and vomiting in the observation group was significantly lower than that in the control group, with statistical significance (P <0.05). Discussion: The use of nylestriol and misoprostol in the treatment of postmenopausal women with intrauterine device removed preoperative process, the exact effect of small side effects, is the ideal treatment for postmenopausal women with IUD removal method.