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目的:探讨支气管肺泡灌洗液(Bronchoalveolar Lavage Fluid,BALF)技术应用于儿科重症支原体肺炎(Severe Mycoplasma Pneumoniae Pneumonia,SMPP)对患儿的血清炎症因子表达影响及肺功能的变化,旨在为临床上SMPP的诊治提供科学参考。方法:回顾性选取我院收治的SMPP患儿83例,按照治疗方式不同,分为两组,对照组41例,静滴阿奇霉素,研究组42例,采用静滴阿奇霉素3-5天行BALF灌洗生理盐水+布地奈德治疗。于治疗7 d后对比两组治疗前后及组间肺功能和炎症指标的变化。结果:研究组IL-2、IL-6、IL-10表达水平均较对照组显著降低,差异有统计学差异(P<0.05);研究组mPAP、PAWP、PVR均比对照组下降明显,差异有显著性意义(P<0.05)。结论:BALF技术可明显改善患儿炎症因子表达,对促进患儿肺功能恢复正常有良好作用,适用于儿童SMPP的治疗。
Objective: To investigate the effect of Bronchoalveolar Lavage Fluid (BALF) on Serum Inflammatory Cytokine Expression and Lung Function in Pediatric Patients with Severe Mycoplasma Pneumoniae Pneumonia (SMPP) SMPP diagnosis and treatment to provide scientific reference. Methods: Eighty-three children with SMPP admitted to our hospital were retrospectively selected. According to the different treatment methods, they were divided into two groups: control group, 41 cases, intravenous azithromycin, study group, 42 cases. Wash saline + budesonide treatment. After 7 days of treatment, changes of lung function and inflammation index in two groups before and after treatment were compared. Results: The expression levels of IL-2, IL-6 and IL-10 in the study group were significantly lower than those in the control group (P <0.05); the mPAP, PAWP and PVR in the study group were significantly lower than those in the control group There was significant (P <0.05). Conclusion: BALF technique can significantly improve the expression of inflammatory cytokines in children and promote the recovery of pulmonary function in children. It is suitable for the treatment of children with SMPP.