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乙型肝炎（乙肝）病毒（HBV）感染是严重的全球公共卫生问题。目前临床治愈是乙肝治疗的理想终点，即患者完成治疗后血清乙肝病毒表面抗原阴性，伴或不伴乙肝病毒表面抗体出现，HBV DNA检测不到，肝脏生物化学指标正常，肝脏组织病变得到改善。然而，基于现有的治疗药物难以获得令人满意的临床治愈效果，为此，科学工作者们进行了诸多探索，不论是联合核苷（酸）类似物和聚乙二醇干扰素的治疗策略，还是适时终止抗病毒药物治疗，抑或是加速创新药物的研发，目前都充满着机遇与争议。乙肝临床治愈之路道阻且长，但行则将至，我们始终相信，经过不懈努力，帮助慢性乙肝患者获得临床治愈甚至完全治愈的梦想终会实现。“,”Hepatitis B virus (HBV) infection is a serious global public health issue. At present, clinical cure is the ideal endpoint for hepatitis B treatment. That is to say, after the completion of treatment, the serum hepatitis B virus surface antigen (HBsAg) is negative, with or without the presence of antibody against hepatitis B virus surface antigen (anti-HBs), undetectable HBV DNA, liver biochemical indicators within normal range, and improved liver tissue lesions. However, it is difficult to achieve a satisfactory clinical cure effect based on the existing therapeutic drugs. To this end, scientists have conducted many explorations, whether it is a combination of nucleos(t)ide analogues and pegylated interferon therapy strategies, or timely termination of antiviral drug treatment, or accelerate the research and development of innovative drugs. The road to clinical cure of hepatitis B is obstructive and long, with full of opportunities and controversies, but the lead is about to come. We always believe that through unremitting efforts, the dream of helping chronic hepatitis B patients to obtain clinical cure or even complete cure will eventually come true.