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目的探讨无淋巴结转移的直肠癌中nm23－H1、p21表达与预后的关系。方法应用免疫组织化学方法观察84例无淋巴结转移的直肠腺癌nm23－H1、p21的表达。结果在生存期＜5年的32例患者中，nm23－H1阴性表达着26例（81．3％），p21阳性表达者28例（87．5％），在生存期＞5年的52例患者中，nm23－H1阴性表达者11例（21．2％），p21阳性表达着20例（38．5％），nm23－H1及p21在2组中表达差异有显著性（P＜0．05）。结论无淋巴结转移的直肠癌中nm23－H1低表达及p2I阳性表达与5年生存率密切相关，这对术后综合治疗方案选择有指导作用。
Objective To investigate the relationship between the expression of nm23-H1 and p21 and prognosis in rectal cancer with no lymph node metastasis. Methods Immunohistochemistry was used to observe the expression of nm23-H1 and p21 in 84 cases of rectal adenocarcinoma without lymph node metastasis. Results Of the 32 patients with a survival period of less than 5 years, 26 cases (81.3%) were negative for nm23-H1 expression, 28 (87.5%) were positive for p21 expression, and 52 cases had a survival period of >5 years. In patients, nm23-H1 negative expression in 11 cases (21.2%), p21 positive expression in 20 cases (38.5%), nm23-H1 and p21 in the two groups showed a significant difference (P <0. 05). Conclusion The low expression of nm23-H1 and the positive expression of p2I in rectal cancer without lymph node metastasis are closely related to the 5-year survival rate, which has a guiding role in the choice of postoperative comprehensive treatment options.