【摘 要】
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High-fat diet (HFD) could induce obese and microbial dysbiosis,the latter of which has great impact on host health.Dietary polysaccharides are well known to have a wide range of biological benefits for bowel health.In this study,we investigated the effect
【机 构】
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Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences,Oil Crops and Lipids Pr
论文部分内容阅读
High-fat diet (HFD) could induce obese and microbial dysbiosis,the latter of which has great impact on host health.Dietary polysaccharides are well known to have a wide range of biological benefits for bowel health.In this study,we investigated the effects of rapeseed polysaccharide (RSP) on overweight and gut microbiota in high-fat-diet (HFD) fed rats.RSP effectively alleviated the hyperglycemia and lipid metabolic disorder in serum,which was found closely related to the modulation of intestinal microbiota.Supplementation of RSP regulated the in-testinal microbiome by increasing the proportion of butyrate acid producer Blautia (P ＜ 0.05),Dorea (P ＜ 0.01)and Akkermansia genus and inhibiting the growth of bacterial species associated with inflammation such as un-classified Ruminococcaceae (P ＜ 0.05).Moreover,the restoration of total short-chain fatty acids (SCFAs),espe-cially propionate and butyrate might be an important strategy for mitigating HFD induced metabolic disorders.Our results suggested that RSP is a potential prebiotic for preventing obese induced HFD through regulating the gut microbiota.
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