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传统用于治疗肠伤寒的抗生素是氯霉素,但此药有潜在严重副作用和10～15%的复发率,患者体温恢复正常需3～5天,疗程至少2周。氨苄青霉素、阿英西林或TMP-SMZ亦需要相当长的疗程。一些作者报告用头孢菌素治疗伤寒,特别是第三代头孢菌素,如头孢三嗪和Moxalactam,诚然这些药物是有效的,但也有缺点,如必须非胃肠道给药,必须用大剂量或10天以上的疗程,以减少其复发率,而且价格昂贵。新喹诺酮是治疗伤寒的有效药物,可口服,体外试验对沙门氏菌有效,具有令人满意的药理学特性和良好的细胞穿透力。无论
The traditional antibiotic used to treat typhoid is chloramphenicol, but this drug has potentially serious side effects and a relapse rate of 10-15%. Patients should return to normal temperature for 3-5 days for at least 2 weeks. Ampicillin, ampicillin or TMP-SMZ also require a rather long course of treatment. Some authors report the use of cephalosporins in the treatment of typhoid fever, particularly the third generation cephalosporins such as ceftriaxone and Moxalactam, although these drugs are, of course, effective, but also have drawbacks such as the need for parenteral administration and the need for high doses Or more than 10 days of treatment to reduce the recurrence rate, but also expensive. New quinolones are effective drugs for the treatment of typhoid fever and are available orally in vitro and are effective against Salmonella with satisfactory pharmacological properties and good cell penetration. regardless