目的 研究曲格列酮的合成路线。方法 为避免选择性醚化反应，将前两步（还原和选择性醚化）反应，重新设计和调整为三步反应，即酯化、醚化和还原反应。结果 每步反应专属性较强。有二个新的化合物（Ⅱ）和（Ⅲ）生成；整个反应革除了用柱色谱分离而直接得到产物。结论 酚醚化反应收率为９８％，比文献报道提高了１０％以上。总收率约为１７％，并有工业化生产的可能。 Objective To study the synthetic route of troglitazone. Methods To avoid selective etherification, the first two steps (reduction and selective etherification) were redesigned and adjusted to three-step reactions, ie esterification, etherification and reduction. The results of each reaction is more specific. Two new compounds (II) and (III) were formed; the entire reaction was obtained directly without isolation by column chromatography. Conclusion The yield of phenol etherification is 98%, which is 10% higher than that reported in the literature. The total yield of about 17%, and the possibility of industrial production.