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采用双抗体夹心酶联免疫吸附 (ELISA)法 ,检测了支气管哮喘患者发作期 30例、缓解期 2 0例患者以及健康对照者 (2 0例 )血中可溶性细胞间粘附分子 (sICAM 1)水平和IgE水平。结果 ,支气管哮喘患者急性发作期、缓解期的sICAM 1水平和IgE水平较健康对照者显著升高 (P <0 .0 5 ) ,缓解期患者sICAM 1水平和IgE水平较急性发作期明显下降。认为血液中sICAM 1与IgE参与了支气管哮喘的发病过程 ;监测sICAM 1水平 ,对判断哮喘发作有十分重要的意义
Serum levels of soluble intercellular adhesion molecule (sICAM 1) in 30 patients with bronchial asthma, 20 patients with bronchial asthma and 20 healthy controls (20 controls) were detected by double antibody sandwich enzyme-linked immunosorbent assay (ELISA) Level and IgE levels. As a result, the levels of sICAM 1 and IgE in patients with bronchial asthma during acute exacerbation and remission were significantly higher than those in healthy controls (P <0.05). The levels of sICAM 1 and IgE in patients with remission were significantly lower than those in patients with acute exacerbation. It is considered that sICAM 1 and IgE in the blood are involved in the pathogenesis of bronchial asthma. Monitoring the level of sICAM 1 is of great significance in judging the onset of asthma