论文部分内容阅读
目的探讨胰岛素强化治疗对出诊Ⅱ型糖尿病胰岛-β细胞功能的影响。方法对68例Ⅱ型糖尿病患者行3个月胰岛素强化治疗,治疗前后行糖负荷实验,检测空腹及餐后2h血糖、胰岛素、C-肽水平。结果初诊Ⅱ型糖尿病行胰岛素强化治疗后的患者血糖、胰岛素、C-肽水平在60min、120min、180min差异有统计学意义(P<0.05),而经保守治疗5年以上药物继发失效,再行强化治疗患者则无此差异。结论初诊Ⅱ型糖尿病行胰岛素强化治疗后可减少高血糖毒性作用,改善胰岛-β细胞功能,使部分胰岛-β细胞得到修复。而保守治疗时间长、见效慢、胰岛素分泌差者,胰岛-β细胞呈不可逆性衰竭。
Objective To investigate the effect of intensive insulin therapy on the function of islet-β cells in type Ⅱ diabetic patients. Methods Sixty-eight patients with type 2 diabetes mellitus underwent three months of intensive insulin therapy. Before and after treatment, glucose load was measured and fasting blood glucose, insulin and C-peptide levels were measured 2h after meal. Results The level of blood glucose, insulin and C-peptide in patients with newly diagnosed type 2 diabetes mellitus were significantly lower at 60min, 120min and 180min (P <0.05), while those treated conservatively for more than 5 years were secondary to failure Intensive treatment of patients is no such difference. Conclusions The newly diagnosed type 2 diabetes patients underwent intensive insulin therapy can reduce the hyperglycemic toxicity and improve the function of islet-β cells, so that some islet-β cells can be repaired. The conservative treatment for a long time, effective slow, poor insulin secretion, islet-β cells showed irreversible failure.