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柳丁氨醇是一种选择性β_2受体激动剂,属于异两基肾上腺素族药物。本文介绍它对严重心肌疾患(充血性心肌病)的心血管作用。方法:12例临床及心导管证实为严重充血性心肌病的患者,平均45岁(32～65岁)。尽管经习用的抗心力衰竭治疗,均仍有顽固性心力衰竭,且均有呼吸困难。无1例有缺血性、心瓣膜疾患、高血压或糖尿病。所有患者均曾用洋地黄和利尿剂治疗。心电图示1例有心房颤动,所有病例T波均倒置,部份伴以ST段压低,提示有洋地黄作用。胸片显示心脏增大,心胸比例平均为64％(62～70％),造影显示左心室增大而扩张,呈普遍的低动力状态,冠状血管均正常,从而证实了充血性心肌病的诊断。
Salbutamol is a selective β_2 receptor agonist, belonging to heterobiglyceridoid drugs. This article describes its cardiovascular effects on severe heart disease (congestive cardiomyopathy). METHODS: Twelve patients (mean age 45 years (range, 32-65 years)) with clinical and cardio catheter confirmed severe congestive cardiomyopathy. Despite the conventional anti-heart failure treatment, there are still refractory heart failure, and both have breathing difficulties. None had ischemic, valvular heart disease, high blood pressure, or diabetes. All patients were treated with digitalis and diuretics. One case of ECG showed atrial fibrillation, T wave were inverted in all cases, some accompanied by ST depression, suggesting digitalis role. Chest radiographs showed an increase in heart size with an average 64% (62- 70%) of the cardiothoracic and angiographic findings indicating an enlargement and expansion of the left ventricle as a general low-power condition with normal coronary vessels confirming the diagnosis of congestive cardiomyopathy .