我们筛选出针对内皮素１（ＥＴ１） 前体基因反义硫代寡核苷酸片断（ＥＴＡＳＯＤＮ） ，已证明ＥＴＡＳＯＤＮ能显著抑制培养内皮细胞ＥＴ１ 的生成（ Ｐ＜ ０－０５） 。本实验应用该片断，对正常和腹主动脉狭窄高盐摄入型高血压大鼠侧脑室进行注射， 记录注射前后血流动力学指标、注射后侧脑室周围组织中ＥＴ１ 的含量及分布， 观察ＥＴＡＳＯＤＮ 对正常和高血压大鼠的影响， 发现高血压大鼠脑干ＥＴ１ 含量明显高于正常大鼠（ Ｐ＜ ０－０５） ；ＥＴＡＳＯＤＮ能降低高血压大鼠脑干ＥＴ１ 水平（ Ｐ＜ ０－０５） 、平均动脉压（ ＭＡＰ）（ Ｐ＜ ０－０１） 、心率、左心室收缩压（ Ｐ＜ ０－０５） ， 降低正常大鼠下丘脑ＥＴ１ 水平、ＭＡＰ（ Ｐ＜ ０－０５） ； 注射ＥＴＡＳＯＤＮ后， 大鼠高血压组△ＭＡＰ显著低于正常组。结果表明：ＥＴＡＳＯＤＮ 能抑制大鼠部分心血管中枢ＥＴ１ 的生成， 参与正常和腹主动脉狭窄高盐摄入型高血压大鼠血压的中枢调节机制 We screened for endothelin 1 (ET 1) precursor gene antisense oligonucleotide oligonucleotide fragments (ETASODN), ETASODN has been shown to significantly inhibit endothelial cell ET 1 production (P <0-05) . In this study, we used this fragment to inject the lateral ventricle of normal and hypertensive rats with abdominal aortic stenosis and high salt intake, record the hemodynamic parameters before and after injection, the content of ET-1 in the periventricular tissue after injection, Distribution, ETASODN observed in normal and hypertensive rats, found that hypertensive rat brainstem ET 1 content was significantly higher than normal rats (P <0-05); ETASODN can reduce hypertensive rats brain stem ET 1 level (P <0-05), mean arterial pressure (MAP) (P <0-01), heart rate and left ventricular systolic pressure (P <0-05) (P <0-05). The △ MAP of hypertensive rats after ETASODN injection was significantly lower than that of normal rats. The results showed that ETASODN can inhibit ET-1 production in some cardiovascular centers of rats and is involved in the central regulation of blood pressure in normal and hypertensive rats with abdominal aortic stenosis and high salt stress