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作者对39例连续收治的新确诊急粒、早幼粒、红血病、急粒-单(AMML)患者,在应用柔红霉素和阿糖胞苷治疗前均作了脑脊液(CSF)检查。将1.5毫升的脑脊液加入小牛血清0.5毫升,取1.0毫升置于 Shan-don Elliot 细胞离心沉淀器中。100rpm 离心沉淀4分钟,待细胞沉淀于预先涂有1%牛清蛋白的玻片上待干,用 Jenner-Giemsa 法染色镜检。凡发现原始细胞者,每周鞘注 Ara-c 30mg/m~2)一次,连续5次或继续用药直至阴转为止。39例中7例阳性,均为 AMML,无一例属于急粒或早幼粒(P<0.005),余32例为阴性。阳性的7例中,2例伴有中枢神经系统白血病(CNSL)的临床症状,其中1例常规细胞计数正常,1例起初未予治疗,后来 CSF 细胞数增多;1例虽无症状,但随后细胞数增多;2例蛋白质增多,1例虽每立方毫米只有2个原始细胞,却有颈强和乳头水肿。完全缓解的22
The authors performed cerebrospinal fluid (CSF) examination of 39 newly diagnosed patients with acute granuloma, promyelocytic, erythroleumatic, and acute-amyloid (AMML) patients who were treated with daunorubicin and cytarabine successively. . 1.5 ml of cerebrospinal fluid was added to 0.5 ml of calf serum, and 1.0 ml was placed in a centrifugal sedimenter of Shan-don Elliot cells. After centrifugation was performed at 100 rpm for 4 minutes, cells were precipitated on slides pre-coated with 1% bovine albumin and dried, and examined by Jenner-Giemsa staining. For those who found the original cells, weekly Ara-c 30mg/m~2) was administered once, 5 times in a row or until the negative rotation. Of the 39 cases, 7 cases were positive, all of them were AMML, none of which belonged to acute granules or promyelocytic leukemia (P<0.005). The remaining 32 cases were negative. Of the 7 positive cases, 2 were associated with clinical symptoms of central nervous system leukemia (CNSL), of which 1 had a normal cell count, 1 had no treatment at first, and later had an increase in the number of CSF cells; 1 had no symptoms, but then The number of cells increased; in 2 cases, there was an increase in protein. In one case, there were only 2 primitive cells per cubic millimeter, but there was neck edema and papilledema. Completely relieved 22