近年对淋巴细胞介质的研究成了细胞免疫学的活跃领域。虽然20多年来人们己知,丝裂原刺激的脾细胞可以产生在体内能加强免疫反应的淋巴因子,但新近却是能在体外使激活的 T 细胞持续生长的 T 细胞生长因子(T-cell growth factor,TCGF)显得特别重要。在体内 TCGF 的重要性在于控制 T 细胞的克隆扩增及反应。在体外,由于 TCGF 可以选择不同功能的 T 细胞克隆促其生长,如胞毒性 T 细胞(CTL)或辅助性 T 细胞(TH),故更有其重要性。人们第一次可以对具有已知抗原特异性的 T 细胞亚群的单个克隆进行研究,这就有可能去鉴定单个克隆的 In recent years, the study of lymphocyte media has become an active area of ​​cellular immunology. Although it has been known for more than two decades that mitogen-stimulated splenocytes produce lymphokines that enhance the immune response in the body, the more recent ones are the T-cell (T-cell) growth factor (TCGF) is of particular importance. The importance of TCGF in vivo lies in controlling the clonal expansion and response of T cells. In vitro, it is even more important because TCGF can select different functional T cell clones to promote its growth, such as CTL or TH. For the first time, one can study individual clones of T cell subsets with known antigen specificity, which makes it possible to identify individual clonal