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目的研究更昔洛韦药物树脂交换动力学与热力学。方法用动边界模型描述了更昔洛韦交换过程的动力学;用热力学参数描述了更昔洛韦交换过程的热力学。结果确定更昔洛韦交换行为的速度控制步骤为颗粒扩散,更昔洛韦交换过程的表观活化能为-27.95kJ·mol-1,交换反应的自由能变化△G>0,焓变△H0m<0,熵变△S<0。结论通过对更昔洛韦与树脂的动力学与热力学研究,为更昔洛韦药物树脂释药系统提供理论依据。
Objective To study the kinetics and thermodynamics of ganciclovir drug exchange. The kinetic model of ganciclovir exchange process was described by the dynamic boundary model. The thermodynamics of ganciclovir exchange process was described by thermodynamic parameters. The results showed that the rate controlling step of ganciclovir exchange was particle diffusion, the apparent activation energy of ganciclovir exchange process was -27.95 kJ · mol-1, the free energy change △ G> 0 and the enthalpy change △ H0m <0, entropy change △ S <0. Conclusion The study of kinetics and thermodynamics of ganciclovir and resin provides a theoretical basis for ganciclovir drug delivery system.