已有报道,荷瘤动物和癌症患者尿中各种变性核苷排泄水平升高.这些核苷主要来自转运糖核核酸(tRNA)。尿中变性核苷的升高,系因肿瘤组织中,tRNA的周转率高于健康组织,而不是由于细胞死亡所致。这些变性核苷,不能再被利用,而作为完整的分子从尿中排泄。在这些变性核苷中,假性尿核苷的浓度升高最常见,也最明显. It has been reported that urinary excretion of various denatured nucleosides is elevated in tumor-bearing animals and cancer patients. These nucleosides are mainly derived from transporter nuclear nucleic acid (tRNA). The increase in urinary denatured nucleosides is due to the higher turnover rate of tRNA in tumor tissue than to healthy tissue, not to cell death. These denatured nucleosides can no longer be used but are excreted as complete molecules from the urine. Among these denatured nucleosides, the increase in the concentration of pseudo-uridine is the most common and the most obvious.