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呋喃二氢吡啶二羧酸酯(EFDP)9mg/kg iv可明显对抗乌头碱诱发大鼠的心律失常,转窦率为100％;使CaCl_2所致的大鼠室颤发生率降低86％;结扎大鼠左冠状动脉引起的心律失常发生率降低83％;并能提高豚鼠心脏对哇巴因中毒时的耐量,与溶剂对照组比较,使出现室早、室速、室颤和心脏停搏时的哇巴因用量分别增加50,66,68和59μg。给氯仿-肾上腺素的6只家兔用iv EFDP4.5mg/kg则均未发生心律失常。EFDP 23～46mg/kg ip使氯仿引起的小鼠室颤发生率分别减少53％和73％。EFDP 19.6μmol/L冠脉给药,离体兔心在缺血再灌注期间无心律失常发生。结果表明,EFDP具有显著的抗实验性心律失常作用。
Furan dihydropyridine dicarboxylate (EFDP) 9mg / kg iv can significantly antagonize aconitine-induced arrhythmia in rats, the turn rate was 100%; CaCl2-induced rat ventricular fibrillation rate was reduced 86%; Ligation of the left coronary artery caused by the incidence of arrhythmia decreased by 83%; and can improve guinea pig heart tolerance to ouabain poisoning compared with the solvent control group, so that the emergence of early ventricular tachycardia, ventricular fibrillation and cardiac arrest The amount of ouabain was increased by 50, 66, 68 and 59 μg, respectively. Arrhythmia was absent in all 6 rabbits given chloroform-epinephrine iv iv at 4.5 mg / kg. EFDP 23-46 mg / kg ip reduced the incidence of ventricular fibrillation induced by chloroform by 53% and 73%, respectively. EFDP 19.6μmol / L coronary administration, isolated rabbit heart during ischemia-reperfusion no arrhythmia. The results show that, EFDP has significant anti-experimental arrhythmia.