防腐剂在滴眼剂中的应用广泛。已有很多研究显示,长期应用含防腐剂的滴眼剂会对角膜结膜上皮细胞产生不良反应。活性氧的产生是加防腐剂的滴眼剂诱导细胞凋亡的最根本机制。玻璃酸钠具有抗氧化、保湿、润滑、促修复等作用,可有效降低滴眼剂中防腐剂的不良反应。就防腐剂的不良反应机制及玻璃酸钠如何降低其不良反应进行综述。 Preservatives are widely used in eye drops. Many studies have shown that long-term use of preservative-containing eye drops on the corneal conjunctival epithelial cells produce adverse reactions. The production of active oxygen is the most fundamental mechanism of apoptosis induced by preservative-containing eye drops. Sodium hyaluronate has the functions of anti-oxidation, moisturizing, lubrication, promoting repair and the like, and can effectively reduce the adverse reactions of preservatives in eye drops. The mechanism of adverse reactions of preservatives and how sodium hyaluronate reduced its adverse reactions were reviewed.