论文部分内容阅读
虽知环氧化物在多环烃代谢过程中生成,但前者是否为后者致癌作用的活性中间代谢物尚不明确。已观察了一些多环烃及其“K 区”环氧化物致癌作用的活性,但结果矛盾。作者选用了体外-体内试验系统。将年龄为一个月的 BALB/C 雌小鼠的肺组织作移植物,放入含4微克/毫升试验化合物的 Trowell 氏基质中温培30分钟,然后放入单独的基质中24小时以除去任何残余的致癌物,再将移植物植入年龄为2～
Although it is known that epoxides are formed during the metabolism of polycyclic hydrocarbons, it is not clear whether the former is the active intermediate metabolite of the latter carcinogenesis. Some polycyclic hydrocarbons and their “K region” epoxide carcinogenic activity have been observed, but the results are contradictory. The authors used an in vitro-in vivo test system. A lung graft of BALB/C female mice aged one month was implanted in Trowell’s matrix containing 4 μg/ml of test compound for 30 minutes, then placed in separate media for 24 hours to remove any residual Carcinogens, and implant the graft at an age of 2 to