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采用硫队巴比妥酸试验测定丙二醛含量反映脂质过氧化程度。用林县粮食中分离的互隔交链孢霉的代谢物交链孢酚(AOH,体外攻击人胎儿食管及胃上皮后观察对相应组织脂质过氧化的影响,AOH可使4人胎儿食管及胃上皮丙二醛含量明显升高(P?0.01),其程度与AOH剂量有关,并随时间延长,其程度增高,4～5h达高峰、食管对AOH反应较胃强烈,提示AOH可引发食管及胃上皮组织的脂质过氧化,并有一定的器官选择性。据结果可推测AOH可能是林县地区人食管癌病因之一。
The use of the sulfur group barbituric acid test to determine the content of malondialdehyde reflects the degree of lipid peroxidation. The effects of AOH, a metabolite of Alternaria alternans isolated from Lin County foodstuffs, on the lipid peroxidation of the corresponding tissues observed after in vitro challenge of human fetal esophagus and stomach epithelium, AOH can make 4 human fetal esophagus The content of malondialdehyde in gastric epithelium was significantly increased (P?0.01). The degree was related to the dose of AOH, and it was prolonged with time. Its degree increased, peaked at 4 to 5 hours, and the esophagus responded more strongly to AOH than stomach, suggesting that AOH could cause The lipid peroxidation of esophageal and gastric epithelial tissues, and some organ selectivity, suggest that AOH may be one of the causes of esophageal cancer in Lin County.