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目的分析深圳市首例人感染H5N6禽流感病例流行病学特征,为制定人禽流感防控措施提供依据。方法对人感染H5N6禽流感病例、密切接触者和感染来源进行流行病学调查,采集相关标本进行实验室检测,并应用描述性流行病学方法进行分析。结果病例确诊为人感染H5N6禽流感,临床表现主要为高热、咳嗽、呼吸困难,CT显示双肺实变进展迅速,白细胞正常,因呼吸及循环衰竭死亡;病例有明确的活禽接触史,基因测序结果表明患者标本中H5N6病毒基因与外环境中的病毒基因高度同源,其密切接触者中未发生H5N6禽流感感染;活禽市场广泛受到禽流感病毒污染。结论深圳市首次发现人感染H5N6禽流感病例,感染来源与接触禽类有关,未发现人传人的证据。
Objective To analyze the epidemiological characteristics of the first human case of H5N6 bird flu in Shenzhen and provide evidence for the development of human bird flu prevention and control measures. Methods Epidemiological investigation was conducted on human cases of H5N6 avian influenza, close contacts and sources of infection. Relevant specimens were collected for laboratory testing and analyzed using descriptive epidemiological methods. Results The cases were confirmed as H5N6 bird flu. The main clinical manifestations were high fever, cough and dyspnea. CT showed the rapid progression of double lung solidification, normal white blood cells and death due to respiratory and circulatory failure. The cases had clear live poultry contact history, The results showed that the H5N6 virus gene was highly homologous to the virus in the external environment and no H5N6 bird flu was found in the close contacts of the virus. The live poultry market was widely contaminated with the bird flu virus. Conclusion The first case of H5N6 bird flu was found in Shenzhen. The source of infection was related to contact with birds, and no evidence of human transmission was found.