胰岛素和上皮生长因子(EGF)受体可能有相同的起源,两者胞外结构中富含半脱氨酸的区域具有很大的相似性,胞内有一高度保守的酪氨酸蛋白激酶的结构域,但EGF受体为单肽链,而胰岛素受体则由完全不同的α和β亚基以α_2β_2异源四聚体组成受体复合物,尽管如此,两者在功能上仍有很大 Insulin and epidermal growth factor (EGF) receptors may have the same origin, the two extracellular structures rich in half-amino acid region has a great similarity, intracellular there is a highly conserved structure of tyrosine protein kinase Domain, but the EGF receptor is a single peptide chain, whereas the insulin receptor consists of completely different alpha and beta subunits that make up the receptor complex as the alpha 2 beta 2 heterotetramer, both of which are functionally quite large