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在大鼠的膈肌离体不均匀牵张肌肉标本（ＩＮＳＭＰ）上，肟类化合物双复磷（Ｏｂｉ）和酰胺磷定（ＨＩ－６）对正常神经肌肉接头（ＮＭＪ）具有轻度抑酶作用，在突触后抑制作用的浓度（１．０ｍｍｏｌ／ＬＯｂｉ和０．５，１．０ｍｍ０ｌ／ＬＨＩ－６）下可对抗梭曼致终板区持续性去极化（ＳＤ）的产生。冲洗药物后。Ｏｂｉ的对抗作用完全消失，ＨＩ－６的对抗作用不完全消失。表明Ｏｂｉ和ＨＩ－６主要以突触后抑制作用生理性地对抗梭曼中毒致ＳＤ的产生，其中ＨＩ－６有部分酶重活化作用。也进一步表明ＳＤ是梭曼中毒ＮＭＪ上主要电生理反应，ＳＤ的产生主要是一种突触后机制
The oxime compounds Obi and HI-6 have a slight inhibitory effect on normal neuromuscular junctions (NMJs) on rat isolated diaphragm muscle strips (INSMPs) , The production of sustained depolarization (SD) in the somatopustic plateau region was counteracted at the concentrations of postsynaptic inhibition (1.0 mmol / L LOb and 0.5, 1.0 mmol / L HI-6) After washing the medicine. Obi antagonism completely disappeared, HI-6 antagonistic effect does not completely disappear. Obi and HI-6 showed that the inhibitory effect of somatostatin on the SD induced by soman was physiologically antagonistic, in which HI-6 partially reactivated. It is further demonstrated that SD is the major electrophysiological response to soman intoxication on NMJ and the generation of SD is mainly a post-synaptic mechanism