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核型异常是恶性血液病克隆的一种被广泛承认的标志。在 B-细胞慢性淋巴细胞白血病中(B-CLL)有30％病例具异常三体型核型,也常见易位产生的14q~+染色体。最常见是 t(11;14)(q13;q32)。13号染色体异常,特别是13q12-14在文献中常有报道。但是很少见涉及到6q~-、11q~-和14q~-的异常核型。也有报道高百分比的 B-CLL 患者的正常核型。这种情况是因为 CLL 细胞具正常有丝分裂还是异常克隆中细胞分裂衰弱尚不清楚。我们从遗传学角度建立了一个 B-CLL患者的类淋巴母细胞系。免疫球蛋白重链和
Karyotypic abnormalities are a widely recognized marker of hematological malignancies. In B-cell chronic lymphocytic leukemia (B-CLL), 30% of cases have abnormal trisomic karyotypes, as well as 14q~+ chromosomes that are commonly translocated. The most common is t(11;14)(q13;q32). Abnormal chromosome 13, especially 13q12-14, is often reported in the literature. However, unusual karyotypes involving 6q~-, 11q~-, and 14q~- are rare. Normal karyotypes have also been reported in high percentages of B-CLL patients. This is because it is unclear whether CLL cells have normal or abnormal colony breakdown. We established a lymphoblastoid cell line of B-CLL patients from a genetic perspective. Immunoglobulin heavy chain and