在有易感因素病人中使用氟喹诺酮类药(fluoroquinolones)引起的中枢神经系统副反应(发生率0.9～4.4％)包括头痛、焦燥、头晕、睡眠障碍和癫痫发作。本文报道1例与该类药治疗有关的周围神经病患者。患者,男,37岁,患慢性脊椎骨髓炎,由甲氧西林敏感金黄色葡萄球菌所致,口服培氟沙星400mg 2次/d,可获良好临床与微生物学效应。早先用过其他口服方案(包括氟氯 Central nervous system side effects (0.9 to 4.4%) caused by fluoroquinolones in patients with predisposing conditions include headache, anxiety, dizziness, sleep disorders and seizures. This article reports one case of peripheral neuropathy associated with the treatment of this class of drugs. Patient, male, 37 years old suffering from chronic osteomyelitis caused by methicillin-susceptible Staphylococcus aureus, received pefloxacin 400 mg twice daily for good clinical and microbiological effects. Other oral regimens (including CFCs) were used earlier