β-内啡肽(β-EP)是一种阿片样神经肽,当中枢神经系统受某种刺激时可将其释放入血。本研究的结果表明,当正常人单核细胞(Mon)预先与纯化蛋白衍生物(PPD)及3.2×10~(-3)mol/L的β-EP共同温育18小时后,Mon对PPD的抗原提呈能力(APCP)显著增强(P<0.01),而于相同条件下,加入7.3×10~(-7)mol/L的纳络酮(Nal)时,β-EP对Mon的APCP的增强作用被对消(P>0.05)。以上结果说明β-EP可能是通过作用于阿片受体而增强Mon的APCP的。 Beta-endorphin (beta-EP) is an opioid neuropeptide that is released into the blood when it is stimulated by the central nervous system. The results of this study showed that when monocytes were preincubated with purified protein derivatives (PPD) and 3.2 × 10 -3 mol / L β-EP for 18 hours, Mon had no effect on PPD (APCP) was significantly increased (P <0.01). Under the same conditions, when 7.3 × 10 ~ (-7) mol / L Nal was added, the APCP of Mon The enhancement effect was canceled (P> 0.05). The above results indicate that β-EP may enhance AP AP of Mon by acting on opioid receptors.