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有关环境致突变因素与遗传性疾病之间相互关系研究资料甚少。本文通过对童年时期癌症幸存者的妊娠及后代的研究,以发现可致突变的治疗(放疗、化疗)能否增加流产、严重先天性畸形或性别比率失调的发生。2286例(男性1237例,女性1049例)童年时期癌症幸存者,直接或间接地接受过腹部或性腺放射治疗,或接受过烷化剂化疗,将其与正常人群的先天性畸形和性别比率进行对照比较。1037例女性幸存者有完整的生育史资料,其中944例足月妊
Little is known about the relationship between environmental mutagens and genetic diseases. This article examines the pregnancy and offspring of cancer survivors in childhood to see if mutagenic therapies (radiotherapy, chemotherapy) can increase the incidence of miscarriage, severe congenital malformations, or sex ratio imbalances. 2286 (1237 males and 1049 females) survivors of childhood childhood cancer who have undergone abdominal or gonadal radiotherapy, directly or indirectly, or who have undergone chemoradiation with alkylating agents, undergo congenital malformations and sex ratios in their normal population Comparison comparison. A total of 1,037 female survivors have complete reproductive history information, of which 944 are full-term