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应用间接荧光抗体技术用不同流行性出血热(EHF)疫区的三种鼠肺抗原对安徽EHF患者血清抗体进行检验,其结果如下: 1、用江西省EHF疫区的黑线姬鼠鼠肺抗原检查了25例安徽EHF病人的双清,急性期(1～7天)血清的阴性率为20％(滴度≥1:80);恢复期(19～4天)血清的阳性率为88％(滴度≥1:80),并且两期的抗体滴度有明显的动态化。一般为4倍增高。其中15例达16倍以上。可见两者具有特异的血清学关系。 2、用四川省EHF疫区褐家鼠鼠肺抗原重复检查上述双份血清,得到非常致的结果。 3、通过对另外11份恢复期血清的检查,还确定了辽宁EHF疫区棕背鼠平鼠肺抗顾与上述黑线姬鼠鼠肺抗原的血清学关系。从而证实了辽宁、四川,江西和徽四省EHF的病毒病原的抗原性相同。
Application of indirect fluorescent antibody technology with different epidemic hemorrhagic fever (EHF) outbreaks of three kinds of murine lung antigen in Anhui EHF patients serum antibodies were tested, the results are as follows: 1, Jiangxi province EHF epidemic area Apodemus murine lung Antigen A total of 25 cases of EHF from Anhui were examined. The negative rate of sera from acute phase (1-7 days) was 20% (titer ≥1: 80). The positive rate of sera from the recovery phase (19-4 days) was 88 % (Titer≥1: 80), and the antibody titers of two phases were obviously dynamic. Generally 4 times higher. Of which 15 cases up to 16 times more. Can be seen that the two have a specific serological relationship. 2. Repeatedly examining the above two serums with the EHF-infected Rattus norvegicus lung antigen in Sichuan Province, and obtained very good results. Through the examination of 11 additional convalescent sera, we also confirmed the serological relationship between the lung anti-Gueru mice and the above-mentioned Apodemus agrarius lung antigens in Liaoning EHF epidemic area. It was confirmed that the antigenicity of the EHF virus in Liaoning, Sichuan, Jiangxi and Anhui provinces was the same.