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为了观察恶性肿瘤病人术后细胞免疫功能的变化,我们在50例胃肠道癌术后病人作了三项皮内试验,即OT、SK和PHA试验。发现在术后前6个月和随后6个月初次到门诊就诊的病人之间皮试结果无明显差异。但术后超过一年来诊者其皮试阴性率显著增高。另外,我们还在这50例术后肿瘤病人开始用相应iRNA治疗后、进行了这三项皮内试验以评价iRNA对细胞免疫的作用。结果显示iRNA有显著增加皮试阳性率的效果。
In order to observe the changes in cellular immune function after surgery for patients with malignant tumors, we performed three intradermal tests on 50 patients with gastrointestinal cancer after surgery, namely OT, SK and PHA tests. It was found that there was no significant difference in skin test results between the first 6 months and the first 6 months after the first visit to the outpatient clinic. However, the negative rate of skin test was significantly higher in patients who had been in the clinic for more than one year after surgery. In addition, we also performed these three intradermal tests on these 50 patients with tumors after starting treatment with the corresponding iRNA to evaluate the effect of iRNA on cellular immunity. The results showed that iRNA had a significant increase in the positive rate of skin test.