[目的]探讨中西医治疗创伤性膝关节骨巨细胞瘤的疗效。[方法]对12例膝关节骨巨细胞瘤患者采用自拟中药汤剂内服结合手术进行病灶刮除,95%酒精浸泡灭活,自体髂骨移植合并骨水泥填充的中西医结合疗法进行综合治疗。[结果]12例患者术后均进行随访,随访时间1～4年,平均2年6个月,所有患者均未见肿瘤复发。[结论]中西医结合治疗膝关节骨巨细胞瘤疗效满意。 [Objective] To explore the curative effect of Chinese and Western medicine in the treatment of giant cell tumor of bone in traumatic knee joint. [Methods] Twelve cases of giant cell tumor of knee joint were treated with self-made herbal decoction orally combined with surgery for curettage, 95% alcohol-immersion for inactivation, autologous iliac bone grafting and bone cement-filled traditional Chinese and western medicine combined therapy for comprehensive treatment. . [Results] All the 12 patients were followed up after operation. The follow-up time was 1 to 4 years, with an average of 2 years and 6 months. None of the patients had tumor recurrence. [Conclusion] The curative effect of TCM combined with western medicine on knee giant cell tumor of bone was satisfactory.