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目的比较早中期强直性脊柱炎(ankylosing spondylitis,AS)患者在经益赛普治疗3个月前后血液流变学的变化,探讨益赛普对早中期AS患者血液流变学的影响。方法以141例早中期AS患者采用益赛普治疗3个月,治疗前后分别检测患者血液流变学指标,ESR,CRP和免疫球蛋白(IgA、IgG、IgM),并对两次结果进行比较。结果 AS患者在经益赛普治疗后,全血粘度值(从高切变率到低切变率)、血浆粘度值、红细胞压积、红细胞聚集指数和纤维蛋白原指标均有不同程度的回落(P<0.05)。ESR、CRP和免疫球蛋白(IgA、IgG、IgM)与治疗前均有显著下降(P<0.05)。结论经益赛普治疗的早中期AS患者血液流变学指标得到较好的改善,减少了其它疾病发生的可能性。AS患者治疗过程中血液流变学指标的变化能否成为指导临床治疗的依据之一值得我们继续探讨和研究。
Objective To compare the changes of hemorheology in patients with ankylosing spondylitis (AS) before and after treatment with epristeride for 3 months and to investigate the effect of ipsapril on the hemorheology in patients with early-mid AS. Methods One hundred and forty-one patients with early and mid-stage AS were treated with Yi-Saipu for 3 months. Hemorheological parameters, ESR, CRP and IgA, IgG and IgM were measured before and after treatment, and the results were compared . Results In AS patients, the whole blood viscosity (from high shear rate to low shear rate), plasma viscosity, hematocrit, erythrocyte aggregation index and fibrinogen index all dropped to some extent after treatment with etanercept (P <0.05). ESR, CRP and immunoglobulin (IgA, IgG, IgM) were significantly lower than those before treatment (P <0.05). Conclusion Hematological parameters of early-middle-term AS patients treated with etanercept have been improved, reducing the possibility of other diseases. AS patients during treatment of hemorheological changes can become one of the guidelines to guide the clinical treatment of one of the worthy of our continued discussion and research.